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Researchers in Taiwan used a type of brain scan known as optimized voxel-based morphometry to analyze the anatomy of the brains of 32 young women who reported experiencing moderate to severe menstrual cramps on a regular basis for several years, and 32 young women who did not experience much menstrual pain.

Even when they weren’t experiencing pain, women who had reported having bad cramps had abnormalities in their gray matter (a type of brain tissue), said study author Dr. Jen-Chuen Hsieh, a professor of neuroscience at the Institute of Brain Science at National Yang-Ming University in Taipei, Taiwan.

Those differences included abnormal decreases in volume in regions of the brain believed to be involved in pain processing, higher-level sensory processing and emotional regulation, as well as increases in regions involved in pain modulation and regulation of endocrine function.

Exactly how the changes in the brain could affect women’s experience of pain is unknown, researchers said. But the brain abnormalities suggest that menstrual pain may have similarities with other chronic pain conditions in that over time, repeated bouts of excruciating aches make the brain unusually sensitive to pain — in effect, making the experience of pain worse.

“A long-term bombardment by peripheral pain can elicit plastic changes in the central brain as a reactive adaptation,” Hsieh explained. “It can also be a crucial mechanism that perpetuates the ‘chronification’ of pain” — that is, a mechanism that can turn pain into a lingering affliction.

The study is published in the September issue of PAIN.

Menstrual cramps, or pain in the lower abdomen that occurs when the uterus contracts during menstruation, is the most common gynecological disorder in women of childbearing age, according to background information in the article.

Karen J. Berkley, a professor emeritus of neuroscience and psychology at Florida State University, said menstrual pain is too often not taken seriously.

“This is one of the first groups to call attention to menstrual cramps, the fact that the condition can have an impact on women’s lives, and it’s accompanied by changes in brain anatomy and function,” Berkley said.

Previously, the Taiwanese team reported that women suffering from menstrual cramps also have differences in brain activity as seen by positron emission tomography, another type of brain scan.

“Taken together, those two studies point to the fact that this continual cyclical pain in women is not unimportant,” Berkley said. “

In a study of 16 students enrolled in the 8th grade at an upstate New York middle school, researchers collected information on the kids’ melatonin levels. Levels of melatonin — a hormone that tells the body when it’s nighttime — normally start rising two to three hours before a person falls asleep.

The study authors found that melatonin levels in the teens began to rise an average of 20 minutes later in the spring than in the winter. The teens also reported an average 16-minute delay in sleep onset and an average 15-minute reduction in sleep duration in spring compared to winter.

“This is a double-barreled problem for teenagers and their parents,” study author Mariana Figueiro, an associate professor at the Lighting Research Center at Rensselaer Polytechnic Institute in Troy, N.Y., said in a news release from the institute.

“In addition to the exposure to more evening daylight, many teens also contend with not getting enough morning light to stimulate the body’s biological system, also delaying teens’ bedtimes,” she explained.

This delay in getting to sleep may lead to sleep deprivation and mood changes, and may also increase the risk of obesity and possibly lower school grades, Figueiro noted.

The study is published in the July issue of the journal Chronobiology International.

“This latest study supplements previous work and supports the general hypothesis that the entire 24-hour pattern of light/dark exposure influences synchronization of the body’s circadian clock with the solar day and thus influences teenagers’ sleep/wake cycles,” Figueiro stated in the news release.

“As a general rule, teenagers should increase morning daylight exposure year round and decrease evening daylight exposure in the spring to help ensure they will get sufficient sleep before going to school,” she advised.

SOURCE: Rensselaer Polytechnic Institute, news release.

“We wanted to know if people are going to use genetics as a way to kind of get off the hook, rather than change their behavior and be healthy,” explained study co-author Suzanne C. O’Neill, an assistant professor with the Cancer Control Program at Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C. “But the bottom line is that most people aren’t doing that. It’s only when you look at people with a number of behavioral risk factors that you run into trouble,” she said.

“People, for example, who are smokers and have a poor diet and don’t exercise as much as they should. Those people are more likely to think that diseases are caused by genetics, and are not interested in information on behavioral change. So, the people we want to reach the most are the ones we are going to have the most trouble with,” O’Neill added.

O’Neill, who conducted her research while a postdoctoral student at the social and behavioral research branch of the National Human Genome Research Institute at the U.S. National Institutes of Health, and colleagues reported the survey results in the June 8 online edition of the Annals of Behavioral Medicine.

According to the CDC Foundation, humans are 99.9 percent identical, genetically speaking. It is the minute 0.1 percent remainder that accounts for differences ranging from traits as innocuous as hair color to predispositions for a wide variety of diseases.

With this in mind, the authors set out to assess behavior-related health risk by asking almost 2,000 survey respondents about their daily routines with respect to diet, exercise, smoking, drinking, sun exposure, multivitamin use, body mass index (BMI), and educational background.

In turn, participants were asked to indicate how strongly they believed their behavior, on the one hand, and their genetic background, on the other, would influence disease risk. All were also asked how important it was to them to learn more about healthy behaviors versus genetic risk.

Finally, all participants were asked to outline their family history with respect to eight typically preventable diseases: diabetes, osteoporosis, heart disease, high cholesterol, high blood pressure, and lung, colon and skin cancers.

Evenly split between men and women, more than one-third of the poll participants were college graduates, and nearly two-thirds were married. One-quarter were smokers, one-quarter said they were physically active less than five days a week, and more than one-third reported being obese, the study authors found.

About half of those surveyed said they had a family history with every disease covered by the poll, with the exception of high blood pressure (which touched 83 percent of participants) and osteoporosis (15 percent).

The research team found genetic risk was more likely to be cited as the cause for diabetes, heart disease, high cholesterol, high blood pressure and colon cancer among those with a family history of these diseases.

Those engaged in behaviors that posed the most risk to their health were more likely to attribute cancer risk and high blood pressure risk to genetics, the study authors noted.

Overall, those with the poorest behavior were also the least likely to want more guidance on how healthy behavior could lower disease risk, except with regards to lung cancer, O’Neill and colleagues found.

Nevertheless, while 57 percent of respondents said they wanted more information on genetic risk, 67 percent said they wanted more information on healthy habits.

“It’s important to note that the public as a whole isn’t overly deterministic about genetics,” O’Neill said. “At the same time, it’s not totally surprising that there is this subset of people who are really having a harder time. Both from experience and from the literature, we know that people often don’t want to hear information that is threatening,” she explained.

“But the fact that some people do place a high value on genetic information may actually open up a novel way to talk to them,” O’Neill suggested. “We can introduce the information they are most receptive to — information about genetics — while at the same time getting out the message that behavior does play a huge role in health risk. So, there are ways to approach this problem.”

Lona Sandon, an assistant professor of nutrition at the University of Texas Southwestern Medical Center in Dallas, said that those who might be too quick to point to genetics to explain their health predicament are struggling with the so-called “health-belief mode.”

“First, you have to believe there is a health problem before you can acknowledge there’s something you can do to change that problem,” she explained. “And certainly people who work in public health would say that individual behavior, as well as environmental influences, are the strongest determinants of health outcomes, and that genetics and the medical care we get actually play a very small role in health outcomes, because we typically don’t get to the health-care point until we have disease,” Sandon continued.

“So it’s disease prevention and health promotion where we need to make healthy lifestyle choices, and early on in life,” she said. “We have to prevent it before we’re in our 60s, not after.”

SOURCES: Suzanne C. O’Neill, Ph.D., assistant professor, Cancer Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; Lona Sandon, R.D., assistant professor, nutrition, University of Texas Southwestern Medical Center, Dallas

“Within the past week, we’ve seen a number of workers hospitalized. That’s new,” said Dr. Gina Solomon, a senior scientist with the Natural Resources Defense Council.

More than a dozen workers have been treated at local medical centers for flu-like symptoms ranging from chest pain to dizziness, nausea and headaches, presumably due to exposure to different chemicals emanating from the slick, according to news reports.

The Unified Command in Louisiana — a coalition of government agencies that includes the U.S. Coast Guard, the Department of the Interior and the National Parks Service — last week called back to shore 125 boats helping with the clean-up after medical complaints from crew members.

“The reports that we’ve heard from hospitals and doctors have been [that the symptoms are due to] inhaled irritant exposure, but they’ve not gone so far as to say what exactly they think the responsible agent might be,” Solomon said. “The workers are widely blaming the dispersants.”

Dispersants are chemicals used for the oil clean-up. The solvent used after the massive 1989 Exxon Valdez oil spill off the Alaska coast, for example, was limonene, which can cause skin inflammation and asthma, said Robert Emery, vice president for safety, health, environment and risk management at the University of Texas Health Science Center at Houston.

“There’s no doubt that people are getting sick out there [in the Gulf of Mexico],” Emery said. “The key question is what is it that is causing them to get sick.”

Dr. Stuart Dobbs, chief quality and patient safety officer at The Methodist Hospital in Houston, said: “The more people that are involved, the more problems you’re going to have, particularly respiratory and dermatologic effects.”

“The hydrocarbons that compose the oil and the different components of the oil are all irritating to the skin and all are very aeromatically dispersed, so that means that the odors and the chemicals are present in air. As workers are exposed to it, they’re going to breathe in more and more. It goes along with the smell,” he added.

BP’s Deepwater Horizon exploded and sank in the Gulf of Mexico about 40 miles south of Louisiana on April 20, killing 11 workers and spewing an estimated 21 million to 45 million gallons of crude oil into the water.

BP and the U.S. Coast Guard have said dehydration, heat, food poisoning or other unrelated factors may have caused the workers’ symptoms. The Louisiana Department of Health and Hospitals is investigating, the Associated Press reported.

The U.S. Environmental Protection Agency reports that “air quality levels for ozone and particulates are normal on the Gulf coastline for this time of year.” But, the agency added, it has detected some “odor-causing pollutants associated with petroleum products along the coastline at low levels.” These chemicals could cause headache, nausea and throat irritation.

There have been few studies that have examined the long-term health risks of exposure to oil. Brief contact with small amounts of light crude oil and dispersants aren’t thought to be harmful, the AP reported. But, extended exposure to dispersants can cause central nervous system problems, or damage to the blood, the kidney, or the liver, and leave a metallic taste in the mouth, according to the U.S. Centers for Disease Control and Prevention.

The unprecedented size and duration of this spill makes it unsettling, Solomon said.

“It’s pretty much in every sense a historical spill,” Solomon said. “Previous spills have all happened over a relatively short period of time and then the clean-up effort has mostly been on what’s called weathered oil” — oil that’s been floating on the surface of water for some period of time.

“In this case, we still have fresh oil bubbling up from underwater, which is a completely different situation than has ever been seen before,” she said. “Approximately 40 percent of crude oil evaporates within several hours of reaching the surface of the water. It ends up airborne. It’s really a problem for people who are working out there, especially those closest to where oil is surfacing.”

Clean-up workers are being advised to follow federal guidelines that recommend that anyone involved wear protective equipment such as gloves, safety glasses and clothing, the AP said.

BP CEO Tony Hayward has said the symptoms that workers are reporting — dizziness, headaches, coughing — could be due to any number of causes, including diesel fumes, exhaustion and heat from wearing Tyvek safety suits.

SOURCES: Gina Solomon, M.D., senior scientist, Natural Resources Defense Council; Robert Emery, Dr.P.H., vice president for safety, health, environment and risk management, University of Texas Health Science Center at Houston; Stuart Dobbs, M.D., chief quality and patient safety officer, The Methodist Hospital, Houston; Associated Press

The earlier the children were removed from the orphanage and the longer they lived with their foster family, the larger the reduction in tics. Such tics are common in children with autism, but it is unclear whether they are related to brain damage, the authors note.

“These results underscore the need for early placement in home-based care for abandoned children,” they write in the May issue of Archives of Pediatrics and Adolescent Medicine.

Dr. Charles Nelson, of Children’s Hospital in Boston, and colleagues turned to data from the Bucharest Early Intervention Project, a study conducted at the invitation of the Romanian government by American investigators of 187 current and formerly institutionalized children.

The study assigned 68 children to closely monitored quality foster care, and 68 to remain in an orphanage. The average age was about 23 months.

At the start of the study, more than 60 percent of the children exhibited some or many behavioral tics. (For comparison, only about 20 percent of a group of children raised with their families in the Bucharest area and studied separately by the same group had any such tics.)

While the behaviors declined over time in the children who stayed in the orphanage as well as those who went to foster homes, the latter had fewer tics. At four and a half years into the study, just under half of the institutionalized children still had some or many tics, while just under a third of the foster care kids did.

Age at placement made a big difference; the older the child at placement in foster care the more likely to exhibit tics at each follow-up assessment. At 54 months, none of the children placed before they turned one exhibited any of the studied behaviors, compared to 43 percent of the children placed after the age of two.

Most children placed in foster homes, the authors write, experience a drop in tic activity, “suggesting recovery is possible.”

While most orphanages in the US were closed in favor of foster care by 1970, Nelson said his team’s findings are relevant to poorly chosen and monitored foster care settings that should be considered a form of neglect. “Institutionalization is just a more severe form of neglect,” he told Reuters Health.

The study of Romanian children helps illustrate the need to better understand the role “secure and functional caregiver relationships” plays in creating healthy and resilient children, Dr. David Rubin and Kathleen Noonan, co-directors of the Policy Lab at Children’s Hospital in Philadelphia, write in an editorial accompanying the study.

Researchers aren’t sure about the best way to prevent or treat such tics, which can disrupt daycare, school, and family life, Rubin told Reuters Health. Medications are often the only treatments available, even when talk therapy might work better.

“Our public health systems lag behind in the adoption of these promising interventions,” they write.

SOURCE: http://archpedi.ama-assn.org/cgi/content/short/164/5/406 Archives of Pediatrics and Adolescent Medicine

Natazia contains two female hormones, an estrogen (estradiol valerate) and a progestin (dienogest), and is the first four-phasic oral contraceptive marketed in the United States. Four-phasic refers to the doses of progestin and estrogen varying at four times throughout each 28-day treatment cycle.

“Nearly 12 million women in the United States and more than 100 million women worldwide currently use oral contraceptives,” said Scott Monroe, M.D., director of FDA’s Division of Reproductive and Urologic Products. “The approval of Natazia provides another option for women who choose to use an oral contraceptive as their method of contraception.”

The safety and efficacy of Natazia as an oral contraceptive was evaluated in two multicenter phase 3 clinical trials in North America and Europe. The trials involved 1,867 women and nearly 30,000 28-day treatment cycles. Natazia was found to be effective as a hormonal contraceptive in both studies.

The most common side effects observed with Natazia include irregular bleeding, breast tenderness, headaches, nausea and vomiting, increased weight, and acne. Women older than 35 who smoke should not use this product. Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive use.

Natazia is manufactured by Bayer HealthCare Pharmaceuticals of Wayne, N.J.

The analysis included data from more than 4,600 participants in the Los Angeles Latino Eye Study (LALES). Most of the study participants were of Mexican descent and aged 40 and older. In the four years after the participants enrolled in the study, the Latinos’ rates of visual impairment and blindness were the highest of any ethnic group in the country, compared to other U.S. studies of different populations.

Nearly 3 percent of the study participants developed visual impairment and 0.3 percent developed blindness in both eyes. Among those aged 80 and older, 19.4 percent became visually impaired and 3.8 percent became blind in both eyes.

The study also found that 34 percent of participants with diabetes developed diabetic retinopathy (damage to the eye’s retina), with the highest rate among those aged 40 to 59. The longer someone had diabetes, the more likely they were to develop diabetic retinopathy — 42 percent of those with diabetes for more than 15 years developed the eye disease.

Participants who had visual impairment, blindness or diabetic retinopathy in one eye at the start of the study had high rates of developing the condition in the other eye, the study authors noted.

The researchers also found that Latinos were more likely to develop cataracts in the center of the eye lens than at the edge of the lens (10.2 percent versus 7.5 percent, respectively), with about half of those aged 70 and older developing cataracts in the center of the lens.

“This study showed that Latinos develop certain vision conditions at different rates than other ethnic groups. The burden of vision loss and eye disease on the Latino community is increasing as the population ages, and many eye diseases are becoming more common,” Dr. Rohit Varma, principal investigator of LALES and director of the Ocular Epidemiology Center at the Doheny Eye Institute, University of Southern California, said in a news release from the U.S. National Eye Institute.

The findings are published in four reports in the May issue of the American Journal of Ophthalmology.

“These data have significant public health implications and present a challenge for eye care providers to develop programs to address the burden of eye disease in Latinos,” Dr. Paul A. Sieving, director of the National Eye Institute, said in the news release.

The U.S. National Eye Institute provided funding for LALES.